The CureWorks collaborative model will be unconstrained by the status quo, which we believe will lead to more cures in less time, with less risk for all involved.
Our goal is to deliver effective and safe immunotherapies to patients earlier in their treatment cycle. Aggregating diverse data from trials will help us increase our overall understanding and accelerate our rate of progress. This approach maximizes the number of potential candidates to present for FDA review and approval and, ultimately, the therapies CureWorks is able to provide to our patients.
TARGET | INSTITUTION | TRIAL INFO | OFFICIAL TITLE |
---|---|---|---|
CD22+ Leukemia and Lymphoma | Seattle Children's, Riley Hospital for Children, Children's National Hospital, Children's Hospital Los Angeles, Texas Children's Hospital | Active, recruiting, NCT04571138 |
Pediatric And Young Adult Leukemia Adoptive Therapy (PLAT)-07: A Phase 1/2 Study Of CD22-Specific CAR T Cells For CD22+ Leukemia Or Lymphoma |
TARGET | INSTITUTION | TRIAL INFO | OFFICIAL TITLE |
---|---|---|---|
CD33 | Seattle Children's | Active, recruiting, NCT05105152 |
Pediatric and Young Adult Leukemia Adoptive Therapy (PLAT)-08: A Phase 1 Study of SC-DARIC33 in Pediatric and Young Adults With Relapsed or Refractory CD33+ AML |
TARGET | INSTITUTION | TRIAL INFO | OFFICIAL TITLE |
---|---|---|---|
EGFR+ (m806 epitope) Recurrent / Refractory solid tumors | Seattle Children's | Active, Recruiting NCT03618381 |
Phase 1 Study of EGFR806 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults |
TARGET | INSTITUTION | TRIAL INFO | OFFICIAL TITLE |
---|---|---|---|
B7H3+ Recurrent / Refractory Central Nervous System (CNS) tumors | Seattle Children's | Active, Recuriting NCT04185038 |
Phase 1 Study Of B7-H3-Specific CAR T Cell Locoregionalimmunotherapy For Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma And Recurrent Or Refractory Pediatric Central Nervous System Tumors |
TARGET | INSTITUTION | TRIAL INFO | OFFICIAL TITLE |
---|---|---|---|
B7H3, EGFR806, HER2, and IL13-zetakine for pediatric diffuse intrinsic pontine glioma, diffuse midline glioma, and recurrent or refractory Central Nervous System tumors | Seattle Children's | Active, Recruiting NCT05768880 |
Phase 1 Study of B7-H3, EGFR806, HER2, And IL13-Zetakine (Quad) CAR T Cell Locoregional Immunotherapy For Pediatric Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, And Recurrent Or Refractory Central Nervous System Tumors |
TARGET | INSTITUTION | TRIAL INFO | OFFICIAL TITLE |
---|---|---|---|
Recurrent/Refractory Osteosarcoma | Seattle Children's | Active, Recruiting NCT05312411 |
A Phase I Feasibility And Safety Study of Fluorescein-Specific (FITC-E2) CAR T Cells In Combination With Parenterally Administered Folate-Fluorescein (UB-TT170) For Osteogenic Sarcoma |